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Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of fungi that contain psilocybin which turns into psilocin upon ingestion.^[] Biological genera containing psilocybin mushrooms include Psilocybe, Panaeolus (including Copelandia), Inocybe, Pluteus, Gymnopilus, and Pholiotina Psilocybin mushrooms have been and continue to be used in indigenous New World cultures in religious, divinatory, or spiritual contexts.^[4] They are also used as recreational drugs. They may be depicted in Stone Age rock art in Africa and Europe, but are most famously represented in the Pre-Columbian sculptures and glyphs seen throughout North, Central and South America magic mushroom capsules

Composition

magic mushroom capsules composition varies from genus to genus and species to species.^[25] Its principal component is psilocybin which is converted into psilocin to produce psychoactive effect. Besides, psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin may also be present, which can modify the effects of magic mushrooms.

Panaeolus subbalteatus, one species of magic mushroom, had the highest amount of psilocybin compared to the rest of the fruiting body  Certain mushrooms are found to produce beta-carbolines which inhibit monoamine oxidase, an enzyme that breaks down tryptamine alkaloids. They occur in different genera, such as Psilocybe,^[27]Cyclocybe, and Hygrophorus.^[29] Harmine, harmane, norharmane and a range of other l-tryptophan-derived β-carbolines were discovered in Psilocybe species.

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The effects of magic mushroom capsules come from psilocybin and psilocin. When psilocybin is ingested, it is broken down by the liver in a process called dephosphorylation. The resulting compound is called psilocin, responsible for the psychedelic effects.^[30] Psilocybin and psilocin create short-term increases in tolerance of users, thus making it difficult to misuse them because the more often they are taken within a short period, the weaker the resultant effects are Psilocybin mushrooms have not been known to cause physical or psychological dependence (addiction).^[32] The psychedelic effects appear around 20 minutes after ingestion and can last up to 6 hours. Physical effects may occur, including nausea, vomiting, euphoria, muscle weakness or relaxation, drowsiness, and lack of coordination.

As with many psychedelic substances, the effects of psychedelic mushrooms are subjective and can vary considerably among individual users. The mind-altering effects of psilocybin-containing mushrooms typically last from three to eight hours, depending on dosage, preparation method, and personal metabolism. The first 3–4 hours after ingestion are typically referred to as the ‘peak’—in which the user experiences more vivid visuals and distortions in reality. The effects can seem to last much longer for the user because of psilocybin’s ability to alter time perception

Dosage

The dosage of magic mushroom capsules containing psilocybin depends on the psilocybin and psilocin content, which can vary significantly between and within the same species but is typically around 0.5–2.0% of the dried weight of the mushroom. Usual doses of the common species Psilocybe cubensis range around 1.0 to 2.5 g, while about 2.5 to 5.0 g dried mushroom material is considered a strong dose.^[39] Above 5 g is often considered a heavy dose, with 5.0 grams of dried mushroom often being referred to as a “heroic dose”

The concentration of active psilocybin mushroom compounds varies from species to species but also from mushroom to mushroom within a given species, subspecies or variety.^[42] The species Psilocybe azurescens contains the most psilocybin (up to 1.78%).